Muscle relaxers are used in addition to rest, physical therapy, and other measures to relieve discomfort. See Medications for Back Pain and Neck Pain Increase mobility of the affected muscles.If the pain is severe or chronic and does not respond to over-the counter medications, muscle relaxants may be prescribed. doi: 10.1016/j.cell.2017.04.014.Tense, spasming muscles are often the underlying cause of back and neck pain. (2017) Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses. , Leader A., Amir E.D., Elefant N, Bigenwald C., Remark R., Sweeney R., Becker C.D., Levine J.H., Meinhof K., Chow A., Kim-Schulze S., Wolf A., Medaglia C., Li H., Rytlewski J.A., Emerson R.O., Solovyov A., Greenbaum B.D., Sanders C., Vignali M., Beasley M.B., Flores R., Gnjatic S., Pe’er D., Rahman A., Amit I., Merad M. (2017) High-dimensional single cell mapping of cerium distribution in the lung immune microenvironment of an active smoker. RXRs are required for neonatal expansion and maintenance of the serosal macrophage pool and contribute to ovarian cancer progression.

, Le Berichel J., Núñez V., Were F., Jiménez-Carretero D., Sánchez-Cabo F, Merad M., Ricote M. (Editorial).Ĭasanova-Acebes M., Menéndez-Gutiérrez MP., Porcuna J., Álvarez-Errico D., Lavin L., García A., Kobayashi S. Aberrant differentiation of intestinal stem cells due to inflammation-induced mitochondrial dysfunction predicts postoperative recurrence of Crohn’s disease. State of machine and deep learning in histopathological applications in digestive diseases. KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model. , Zee S.Y., Sheridan B.S., Bialkowska A.B., Yang V.W. Shieh J., Chu T.H., Liu Y., Kim J., Ruiz de Sabando A., Kobayashi S. Spatial Characterization of Tumor-Infiltrating Lymphocytes and Breast Cancer Progression. (Book Chapter, Submitted).įassler J., Torre-Healy L.A., Gupta R., Hamilton A.M., Kobayashi S. AI and Pathology: Steering Treatment and Predicting Outcomes. Deep learning-based approach for the characterization and quantification of histopathology in mouse models of colitis. , Shieh J., Ruiz de Sabando A., Kim J., Liu Y., Zee S.Y., Prasanna P., Bialkowska A.B., Saltz J.H., Yang V.W. In combination with cellular and molecular biology techniques, I plan to utilize programmatic spatial analysis of histological specimens to further understand and dissect the inflammatory response in these conditions. Instead of the tumor microenvironment, I will be shifting my focus to the intestinal mucosal niche that is shaped by the acute flares and chronic inflammation present in IBD. However, my goal is still to continue looking into the interplay that can occur between local tissue cues and immune cell interactions. Now in my PhD years, I will be moving away from cancer research and focusing instead on IBD. From here, I developed a desire to study local tissue cues of the tumor microenvironment and the intercellular interactions that occur within this niche. During my gap years, I had the chance to assist on a study that aimed to characterize both the immune response and the specific tumor-driven changes to the immune compartment that occurred in the lesions of early stage (Stage I/II) human lung adenocarcinoma patients. My major interest is in immunology, and my previous work focused on the context of cancer.

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